{"id":1180,"date":"2021-06-27T05:29:05","date_gmt":"2021-06-27T05:29:05","guid":{"rendered":"https:\/\/emergencydrug.com\/?post_type=product&#038;p=1180"},"modified":"2024-09-30T06:24:57","modified_gmt":"2024-09-30T06:24:57","slug":"lorbrexen-lorlatinib-100-mg","status":"publish","type":"product","link":"https:\/\/emergencydrug.com\/ar\/shop\/lorbrexen-lorlatinib-100-mg\/","title":{"rendered":"Lorbrexen (Lorlatinib) 100 MG &#8211; 30 Tablets"},"content":{"rendered":"<p><strong><em>Product Features:<\/em><\/strong><\/p>\n<table width=\"322\">\n<tbody>\n<tr>\n<td>Product Name<\/td>\n<td>: Lorbrexen<\/td>\n<\/tr>\n<tr>\n<td>Generic Name<\/td>\n<td>: Lorlatinib<\/td>\n<\/tr>\n<tr>\n<td>Manufacturer<\/td>\n<td>: Everest Pharma Ltd<\/td>\n<\/tr>\n<tr>\n<td>Indication<\/td>\n<td>: Non small cell lung cancer<\/td>\n<\/tr>\n<tr>\n<td>Formulation<\/td>\n<td>: Tablet<\/td>\n<\/tr>\n<tr>\n<td>Strength<\/td>\n<td>: 100 mg<\/td>\n<\/tr>\n<tr>\n<td>Quantity<\/td>\n<td>: 30 Tablets<\/td>\n<\/tr>\n<tr>\n<td>Storage<\/td>\n<td>: \u00a0Below 25\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>Registrations<\/td>\n<td>: Export Only<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>Lorbrexen 100 mg<\/strong>\u00a0(Lorlatinib), generic Lorbrena is a prescription medicine. It is used to treat metastatic <a href=\"https:\/\/emergencydrug.com\/non-small-cell-lung-cancer\/\">non-small cell lung cancer<\/a> in patients who have a certain type of abnormal anaplastic lymphoma kinase (ALK) gene. These uses in patients who have already received alectinib, ceritinib or both crizotinib. At least 1 other medicine to treat NSCLC that is caused by the ALK gene.<\/p>\n<div class=\"Section\">\n<h4>Recommended Dosage<\/h4>\n<p class=\"First\">The recommended dosage of LORBRENA is 100 mg orally once daily, with or without food, until disease <a href=\"https:\/\/everestpharmabd.com\/products\/Oncology\" target=\"_blank\" rel=\"noopener\">progression or unacceptable toxicity<\/a>.<\/p>\n<p>Swallow tablets whole and chew, crush or split tablets. Do not ingest broken tablets, cracked, or otherwise not intact.<\/p>\n<p>Take Lorbrexen at the<a href=\"https:\/\/emergencydrug.com\/causes-of-lung-cancer-part-1\/\"> same time each day<\/a>. One dose is missed, then take the missed dose. Unless the next dose is due within 4 hours. Please not take 2 doses at the same time to make up <a href=\"https:\/\/emergencydrug.com\/contact-us\/\">for a missed dose<\/a>.<\/p>\n<p>Do not take an additional dose if vomiting occurs after Lorbrexen but continue with the next scheduled dose.<\/p>\n<\/div>\n<div class=\"Section\">\n<h4>Lorlatinib Dosage Modifications for Adverse Reactions<\/h4>\n<p class=\"First\"><span class=\"xmChange\">\u200b<\/span><span class=\"following_xmChange\">The recommended dose reductions are:<\/span><\/p>\n<p><span class=\"xmChange\">\u200b<\/span><span class=\"following_xmChange\">First dose reduction: <a href=\"https:\/\/emergencydrug.com\/shop\/\">Lorbrexen 100 mg orally once daily<\/a>. <\/span><span class=\"following_xmChange\">Second dose reduction: LORBRENA 50 mg orally once daily\u00a0<\/span><\/p>\n<\/div>\n<h4>Disease interactions Lorlatinib 100 mg<\/h4>\n<p>There are 8 disease interactions with Lorbrexen which include:<\/p>\n<ul class=\"interactions ddc-list-column-2\">\n<li class=\"int_2\">Interstitial lung disease<\/li>\n<li class=\"int_2\">Atrioventricular block<\/li>\n<li class=\"int_2\">CNS effects<\/li>\n<li class=\"int_2\">Hepatotoxicity\/hepatic impairment<\/li>\n<li class=\"int_2\">Hyperglycemia<\/li>\n<li class=\"int_2\">Hyperlipidemia<\/li>\n<li class=\"int_2\">Hypertension<\/li>\n<li class=\"int_2\">Severe renal impairment<\/li>\n<\/ul>\n<h4 id=\"professional\" class=\"ddc-anchor-offset\">For Healthcare Professionals<\/h4>\n<p><a href=\"https:\/\/emergencydrug.com\/causes-of-lung-cancer-disease-part-2\/\">Applies to lorlatinib<\/a>: Oral tablet<\/p>\n<h4>Hematologic<\/h4>\n<p>Very common (10% or more): Anemia (52%), thrombocytopenia (23%), lymphopenia (22%).<\/p>\n<h4>Musculoskeletal<\/h4>\n<p>Very common (10% or more): Arthralgia (23%), myalgia\/musculoskeletal pain (17%), back pain (13%), pain in extremity (13%).<\/p>\n<h4>Ocular<\/h4>\n<p>Very common (10% or more): Vision disorder (e.g., diplopia, photophobia, photopsia, vision blurred, visual acuity reduced, visual impairment, vitreous floaters) (15%).<\/p>\n<h4>Metabolic<\/h4>\n<p>Most common (10% or more): Hypercholesterolemia (96%), hypertriglyceridemia (90%), edema (edema peripheral, eyelid edema, face edema, generalized edema, localized edema, periorbital edema, peripheral swelling, swelling) (57%), hyperglycemia (52%), hypoalbuminemia (33%), weight gain (24%), increased lipase (24%), increased alkaline phosphatase (24%), increased amylase (22%), hypophosphatemia (21%), hyperkalemia (21%), hypomagnesemia (21%), Grade 3 or 4 elevations in total cholesterol 17%), Grade 3 or 4 elevations in triglycerides (17%).<\/p>\n<h4>Psychiatric<\/h4>\n<p>Common (10% or more): Cognitive effects (e.g., amnesia, cognitive disorder, dementia, disturbance in attention, memory impairment, mental impairment, attention deficit\/hyperactivity disorder, confusional state, delirium, disorientation, reading disorder) (29%), changes in mood (24%), changes in sleep (e.g., abnormal dreams, insomnia, nightmare, sleep disorder, sleep talking, somnambulism) (10%).<\/p>\n<p>Common (1% to 10%): Hallucinations, mental status changes, (10%).<\/p>\n<h4>Hepatic<\/h4>\n<p>Very common\u00a0(10% or more): Grade 4 ALT\/AST elevation when taken concomitantly with a strong CYP450 3A inducer (50%), Grade 3 ALT\/AST elevation when taken concomitantly with a strong CYP450 3A inducer (33%)<\/p>\n<p>Common (1% to 10%): Grade 2 ALT\/AST elevation when taken concomitantly with a strong CYP450 3A inducer<\/p>\n<h4>Respiratory<\/h4>\n<p>Very common (10% or more): Dyspnea (27%), cough (18%), upper respiratory tract infection (e.g., fungal upper respiratory infection, viral upper respiratory infection) (12%).<\/p>\n<p>Common (1% to 10%): Interstitial lung disease (ILD), pneumonitis.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><strong>For more Oncology medicine, visit our <a href=\"https:\/\/emergencydrug.com\/shop\/\">SHOP<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lorbrexen 100 mg (Lorlatinib) is a potent, brain-penetrant, third-generation inhibitor of ALK and ROS1 tyrosine kinases with broad coverage of ALK mutations. In a phase 1 study, activity was seen in patients with ALK-positive non-small-cell lung cancer, most of whom had CNS metastases and progression after ALK-directed therapy.<\/p>\n<p>100 mg PO qDay with or without food<\/p>\n<p>Continue until disease progression or unacceptable toxicity.<\/p>\n","protected":false},"featured_media":3043,"comment_status":"open","ping_status":"closed","template":"","meta":[],"mc_generic":[373],"brands":[404],"product_cat":[427,426],"product_tag":[306,130],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product\/1180"}],"collection":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/comments?post=1180"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/media\/3043"}],"wp:attachment":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/media?parent=1180"}],"wp:term":[{"taxonomy":"mc_generic","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/mc_generic?post=1180"},{"taxonomy":"brands","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/brands?post=1180"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product_cat?post=1180"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product_tag?post=1180"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}