{"id":1207,"date":"2021-06-29T09:24:34","date_gmt":"2021-06-29T09:24:34","guid":{"rendered":"https:\/\/emergencydrug.com\/?post_type=product&p=1207"},"modified":"2024-10-01T08:34:36","modified_gmt":"2024-10-01T08:34:36","slug":"sunitix-sunitinib-50-mg","status":"publish","type":"product","link":"https:\/\/emergencydrug.com\/ar\/shop\/sunitix-sunitinib-50-mg\/","title":{"rendered":"Sunitix 50 MG (Sunitinib) \u2013 28 Capsules"},"content":{"rendered":"

Product Features:<\/em><\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Product Name<\/td>\n: Sunitix<\/td>\n<\/tr>\n
Generic Name<\/td>\n: Sunitinib<\/td>\n<\/tr>\n
Manufacturer<\/td>\n: Beacon Pharma Ltd<\/td>\n<\/tr>\n
Indication<\/td>\n: Kidney cancer<\/td>\n<\/tr>\n
Formulation<\/td>\n: Capsule<\/td>\n<\/tr>\n
Strength<\/td>\n: 50 mg<\/td>\n<\/tr>\n
Quantity<\/td>\n: 28 Capsules<\/td>\n<\/tr>\n
Storage<\/td>\n: Below 30\u00b0<\/td>\n<\/tr>\n
Registrations<\/td>\n: Export Only<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Sunitix 50 mg (Sunitinib) Capsule is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.<\/p>\n

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Indications<\/h4>\n<\/div>\n
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Gastrointestinal Stromal Tumor (GIST): It indicates the treatment of gastrointestinal stromal tumor after disease progression on or intolerance to imatinib mesylate<\/a>.<\/p>\n

Advanced Renal Cell Carcinoma (RCC): This indicates the treatment of advanced renal cell carcinoma.<\/p>\n

Advanced Pancreatic Neuroendocrine Tumors (pNET): Sunitix indicates the treatment of progressive, well-differentiated pancreatic neuroendocrine tumors in patients with unresectable locally advanced or metastatic disease.<\/p>\n

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Pharmacology<\/h4>\n<\/div>\n
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Sunitinib inhibits cellular signaling by targeting multiple receptor tyrosine kinases (RTKs).<\/p>\n

These include all receptors for platelet-derived growth factors (PDGF-Rs) and vascular endothelial growth factor receptors (VEGFRs). Which play a role in both tumor angiogenesis and tumor cell proliferation<\/a>. The simultaneous inhibition of these targets. Therefore reduces tumor vascularization and triggers cancer cell apoptosis and thus resulting in tumor shrinkage.<\/p>\n

Sunitinib also inhibits CD117 (c-KIT), the receptor tyrosine kinase that (when improperly activated by mutation) drives the majority of gastrointestinal stromal cell tumors. It has been recommended as second-line therapy for patients whose tumors develop mutations in c-KIT that make them resistant to imatinib or who cannot tolerate the drug.<\/p>\n

In addition, Sunitinib binds to other receptors. These include RET, CD114, and CD135. The fact that Sunitix targets many different receptors. It has many side effects, such as classic hand-foot syndrome, stomatitis, and other dermatologic toxicities.<\/p>\n

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Dosage & Administration<\/h4>\n<\/div>\n
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Recommended Dose For GIST And RCC: The recommended dose of medicine for gastrointestinal stromal tumor (GIST) and advanced renal cell carcinoma (RCC) is one 50 mg oral dose that needs to take once daily<\/a>. On a schedule of 4 weeks on treatment followed by 2 weeks off (Schedule 4\/2). Sunitix takes to with or without food.<\/p>\n

Recommended Dose For pNET: The recommended dose of Capsule for pancreatic neuroendocrine tumors (pNET)<\/a> is 37.5 mg taken orally once daily continuously without a scheduled off-treatment period.<\/p>\n

Dose Modification: Dose interruption and\/or dose modification in 12.5 mg increments or decrements recommend based on individual safety and tolerability. The maximum dose administered in the Phase 3 pNET study was 50 mg daily.<\/p>\n

Alternate concomitant medication with no or minimal enzyme inhibition potential is recommended. A dose reduction to a minimum of 37.5 mg (GIST and RCC) or 25 mg (pNET). Daily consider as Sunitix must co-administer with a strong CYP3A4 inhibitor<\/p>\n

Selection of an alternate concomitant medication with no or minimal enzyme induction potential recommend. A dose increase for Sunitix to a maximum of 87.5 mg (GIST and RCC) or 62.5 mg (pNET) daily considers if Sunitix must co-administer with a CYP3A4 inducer. If the dose increases, the patient monitors carefully for toxicit<\/a>y.<\/p>\n

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Interaction<\/h4>\n<\/div>\n
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Increased plasma cone with strong CYP3A4 inhibitors (eg, ketoconazole, ritonavir, itraconazole, erythromycin, clarithromycin, grapefruit juice). Decreased plasma cone with strong CYP3A4 inducers [eg, rifampin, dexamethasone, phenytoin, carbamazepine, phenobarb, St. John’s wort (Hypericum perforatum)]. Anticoagulants, eg, warfarin and acenocoumarol (periodically monitor platelets, prothrombin time\/INR & physical exam).<\/p>\n

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Side Effects<\/h4>\n<\/div>\n
Fatigue, GI disorders, skin discoloration, rash, palmar-plantar erythrodysesthesia, dry skin, hair color changes, mucosal inflammation, asthenia, dysguesia, anorexia, HTN, neutropenia.<\/div>\n<\/div>\n
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Pregnancy & Lactation<\/h4>\n<\/div>\n
Pregnancy Category D. Positive evidence of human fetal risk is based on adverse reactions. From data investigational or marketing experience or studies in humans. But potential benefits may warrant the use of the drug in pregnant women despite potential risks.<\/div>\n
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For any inquiries, please contact us<\/a><\/strong><\/div>\n
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For more Oncology medicine, visit our SHOP<\/a><\/strong><\/div>\n","protected":false},"excerpt":{"rendered":"
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Sunitix 50 mg (Sunitinib) is used to treat gastrointestinal stromal tumors (GIST) in patients who did not respond to or cannot take imatinib. It also treats advanced renal cell carcinoma (RCC) and helps prevent its recurrence in patients who had a kidney removed. Additionally, Sunitinib treats pancreatic neuroendocrine tumors (pNET) in patients with tumors that have worsened and cannot be treated with surgery.<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"featured_media":3160,"comment_status":"open","ping_status":"closed","template":"","meta":[],"mc_generic":[383],"brands":[403],"product_cat":[428,450],"product_tag":[145,277],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product\/1207"}],"collection":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/comments?post=1207"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/media\/3160"}],"wp:attachment":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/media?parent=1207"}],"wp:term":[{"taxonomy":"mc_generic","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/mc_generic?post=1207"},{"taxonomy":"brands","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/brands?post=1207"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product_cat?post=1207"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product_tag?post=1207"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}