{"id":1220,"date":"2021-06-30T05:54:28","date_gmt":"2021-06-30T05:54:28","guid":{"rendered":"https:\/\/emergencydrug.com\/?post_type=product&p=1220"},"modified":"2024-10-01T06:16:30","modified_gmt":"2024-10-01T06:16:30","slug":"ponatinix-ponatinib-45-mg","status":"publish","type":"product","link":"https:\/\/emergencydrug.com\/ar\/shop\/ponatinix-ponatinib-45-mg\/","title":{"rendered":"Ponatinix (Ponatinib) 45 MG \u2013 30 Tablets"},"content":{"rendered":"

Product Features:<\/em><\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Product Name<\/td>\n: Ponatinix<\/td>\n<\/tr>\n
Generic Name<\/td>\n: Ponatinib<\/td>\n<\/tr>\n
Manufacturer<\/td>\n: Beacon Pharma Ltd<\/td>\n<\/tr>\n
Indication<\/td>\n: Chronic lymphocytic leukemia<\/td>\n<\/tr>\n
Formulation<\/td>\n: Tablet<\/td>\n<\/tr>\n
Strength<\/td>\n: 45 mg<\/td>\n<\/tr>\n
Quantity<\/td>\n: 30 Tablets<\/td>\n<\/tr>\n
Storage<\/td>\n: \u00a0Below 25\u00b0C<\/td>\n<\/tr>\n
Registrations<\/td>\n: Export Only<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Ponatinix 45 mg (Ponatinib), generic is a prescription Tablets use to treat of blood cancer which is chronic phase, accelerated phase, or blast phase chronic myeloid leukemia (CML) or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) for whom no other tyrosine kinase inhibitor (TKI) medicines are received. Ponatinix manufactured by Beacon Pharma Ltd. in Bangladesh.<\/p>\n

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Indications<\/h4>\n<\/div>\n
\n

Ponatinib is a kinase inhibitor indicate<\/a>d for the:<\/p>\n

Adult patients with chronic phase, accelerated phase, or blast phase chronic myeloid leukemia (CML)<\/a> or Ph+ ALL for whom no other tyrosine kinase inhibitor (TKI) therapy is indicated.<\/p>\n

Patients with T315I-positive CML (chronic phase, accelerated phase, or blast phase) or T315I-positive Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL).<\/p>\n

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Pharmacology Ponatinib<\/h4>\n<\/div>\n
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Ponatinib inhibited the in vitro tyrosine kinase activity of ABL and T315I mutant ABL with IC 50 concentrations<\/a> of 0.4 nM and 2.0 nM, respectively. In vitro, activity of additional kinases with IC 50 concentrations between 0.1 nM and 20 nM, including members of the VEGFR, PDGFR, FGFR, EPH receptors and SRC families of kinases, and KIT, RET, TIE2, and FLT3. There is viability of cells expressing native or mutant BCR-ABL, including T315I. In mice, treatment with ponatinib reduce the size of tumors<\/a> expressing native or T315I mutant BCR-ABL when compared to controls.<\/p>\n

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Dosage & Administration Ponatinib<\/h3>\n<\/div>\n
\n

Recommended dose: 45 mg taken orally<\/a> once daily with or without food<\/p>\n

Hepatic Impairment: 30 mg orally once daily. Modify or interrupt dosing for hematologic and non-hematologic toxicity<\/a>.<\/p>\n

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Side Effects<\/h4>\n<\/div>\n
\n

The most common non-hematologic adverse reactions<\/a> (\u226520%) were, abdominal pain, rash, constipation, headache, dry skin, arterial occlusion, fatigue, hypertension, pyrexia, arthralgia, nausea, diarrhea, lipase increased, vomiting, myalgia and pain in extremity.<\/p>\n

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Pregnancy & Lactation<\/h4>\n<\/div>\n
\n

\u00a0In animals, it cause fetal harm when administered to a pregnant woman. There are no available data on Ponatinib use in pregnant women. In animal reproduction studies, oral administration of ponatinib to pregnant rats during organogenesis caused adverse developmental effects. At doses lower than human exposures at the recommended human dose. Advise pregnant women of the potential risk<\/a> to a fetus.<\/p>\n

There is no data on the presence of ponatinib in human milk. The effects on the breastfed infant or on milk production.<\/p>\n

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Use in Special Populations<\/h4>\n<\/div>\n
Pediatric Use: Safety and effectiveness not to establish in pediatric patients.<\/div>\n<\/div>\n
\n
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Storage Conditions<\/h4>\n<\/div>\n
\n

Store Ponatinib at room temperature between 20\u00b0 C to 25\u00b0 C.<\/p>\n

 <\/p>\n

For any inquiries please contact us<\/a><\/strong><\/p>\n<\/div>\n

For more Oncology medicine, visit our SHOP<\/a><\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Ponatinix 45 mg is used to prevent blood clots, heart attacks, and strokes. Consult your doctor if you have blood clots, stroke, high blood pressure, high cholesterol, irregular heartbeat, peripheral vascular disease, or heart disease. Seek immediate medical help for symptoms such as chest pain, shortness of breath, dizziness, sudden confusion, trouble speaking, numbness or weakness on one side of the body, severe headache, limb pain, warmth in the lower leg, or swelling in the feet and ankles.<\/p>\n","protected":false},"featured_media":3054,"comment_status":"open","ping_status":"closed","template":"","meta":[],"mc_generic":[380],"brands":[403],"product_cat":[446,440],"product_tag":[152,153],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product\/1220"}],"collection":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/comments?post=1220"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/media\/3054"}],"wp:attachment":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/media?parent=1220"}],"wp:term":[{"taxonomy":"mc_generic","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/mc_generic?post=1220"},{"taxonomy":"brands","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/brands?post=1220"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product_cat?post=1220"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product_tag?post=1220"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}