{"id":1604,"date":"2021-07-27T08:20:53","date_gmt":"2021-07-27T08:20:53","guid":{"rendered":"https:\/\/emergencydrug.com\/?post_type=product&p=1604"},"modified":"2024-09-26T11:27:47","modified_gmt":"2024-09-26T11:27:47","slug":"crizocent-crizotinib-250-mg","status":"publish","type":"product","link":"https:\/\/emergencydrug.com\/ar\/shop\/crizocent-crizotinib-250-mg\/","title":{"rendered":"Crizocent (Crizotinib) 250 MG -60 Capsules"},"content":{"rendered":"

Product Features<\/strong><\/p>\n\n\n\n\n\n\n\n
Product Name<\/td>\n: Crizocent<\/td>\n<\/tr>\n
Generic Name<\/td>\n: Crizotinib<\/td>\n<\/tr>\n
Manufacture<\/td>\n: Incepta Pharma Ltd<\/td>\n<\/tr>\n
Available size<\/td>\n: 60 Capsules<\/td>\n<\/tr>\n
Strengths<\/td>\n: 250 Mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\n

Crizotinib 60 mg is an inhibitor of receptor tyrosine kinases including ALK, Hepatocyte Growth Factor Receptor (HGFR, c-Met), ROS1 (c-ros), and Recepteur d\u2019Origine Nantais (RON). Translocations can affect the ALK gene resulting in the expression of oncogenic fusion proteins. The formation of ALK fusion proteins results in activation and dysregulation of the gene\u2019s expression and signaling which can contribute to increased cell proliferation and survival in tumors expressing these proteins. Crizocent demonstrated concentration-dependent inhibition of ALK, ROS1, and c-Met phosphorylation in cell-based assays using tumor cell lines and demonstrated antitumor activity in mice bearing tumor xenografts that expressed echinoderm microtubule-associated protein-like 4 (EML4)- or nucleophosmin (NPM)-ALK fusion proteins or c-Met.<\/p>\n<\/div>\n

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Indications<\/h2>\n

Crizocent is a kinase inhibitor indicate for the treatment of patients with-<\/p>\n

\u2022 Metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive<\/a><\/p>\n

\u2022 Metastatic NSCLC whose tumors are ROS1-positive<\/a><\/p>\n<\/div>\n

\n

Dosage & Administration<\/h4>\n

Recommended Dose: 250 mg orally, twice daily<\/a>
\n\u2022 Renal Impairment: 250 mg orally, once daily in patients with severe renal impairment (creatinine clearance <30 mL\/min) not requiring dialysis.<\/p>\n

Geriatric Use
\nNo differences in safety or efficacy were observed between older and younger patients. Clinical studies of Crizocent in patients with ROS1-positive metastatic NSCLC<\/a> did not include sufficient numbers of patients age 65 years and older to determine whether they respond differently from younger patients<\/p>\n

Hepatic Impairment
\nCaution should be used in patients with hepatic impairment<\/p>\n

Renal Impairment
\nNo starting dose adjustment is needed for patients with mild (CLcr 60-89 mL\/min) or moderate (CLcr 30-59 mL\/min) renal impairment based on a population pharmacokinetic analysis.
\nIncreased exposure to crizotinib occurred in patients with severe renal impairment (CLcr <30 mL\/min) not requiring dialysis. Crizotinib should administered at a dose of 250 mg taken orally once daily in patients with severe renal impairment not requiring dialysis.<\/p>\n

Pediatric Dose
\nThe safety and effectiveness of Crizotinib in pediatric patients have not been established.<\/p>\n

Side effects<\/h4>\n<\/div>\n
\n

This is not the full list of all side effects that may occur with Crizocent 250 mg.\u00a0 Please seek medical advice<\/a> from your doctor about if you experience serious or unusual side effects. You must seek immediate medical help if you find symptoms of easy bleeding tendencies, Jaundice, breathing problems, heart problems or infections developing<\/a> in your body.<\/p>\n

Drug allergies are quite common and might occur as a result of reaction to active ingredients as well as inactive ingredients. The most common side effects of allergies are: itching, rashes, hives, shortness of breath, low blood pressure, dizziness and loose motions.<\/p>\n<\/div>\n

\n

Precautions<\/h4>\n

Hepatotoxicity: Patients should undergo periodic liver testing<\/a>. Crizotinib should temporarily suspend, dose reduced or permanently suspend.
\n\u2022 Interstitial lung disease (ILD)\/ Pneumonitis: Drug should permanently discontinue in patients with ILD\/ Pneumonitis
\n\u2022 QT interval prolongation: Electrocardiograms and electrolytes in patients who have a history of or predisposition for QTc prolongation, or who are taking medications that prolong QT should monitor. Crizotinib should be temporarily suspend, dose reduce or permanently suspend.
\n\u2022 Bradycardia: Crizotinib can cause bradycardia. Heart rate and blood pressure should regularly monitored. Crizotinib should temporarily suspend, dose reduce or permanently suspend.
\n\u2022 Severe visual loss: Ophthalmological evaluation should be performed. Crizocent should discontinue in severe visual loss.
\n\u2022 Embryo-fetal toxicity: Crizocent can cause fetal harm. Females of reproductive potential should advise of the potential risk to a fetus and use of effective contraception<\/p>\n<\/div>\n

\n

Use in Pregnancy & Lactation<\/h4>\n

Based on its mechanism of action, Crizocent can cause fetal harm when administered to a pregnant woman. There are no available data on the use of Crizotinib during pregnancy. Females of reproductive potential should advise of the potential risk to a fetus and use of effective contraception.
\nThere is no information regarding the presence of Crizotinib in human milk, the effects on the breastfed infant, or the effects on milk production. Because of the potential for adverse reactions in breastfed infants patients should not breastfeed during treatment with Crizotinib and for 45 days after the final dose.<\/p>\n<\/div>\n

\n

Drug Interaction<\/h4>\n

Inhibitors CYP3A : Concurrent use of Crizotinib avoid with strong CYP3A inhibitors including but not limited to atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, troleandomycin, and voriconazole
\nInducers CYP3A: Use of Crizotinib should avoid with strong CYP3A inducers including but not limited to carbamazepine, phenobarbital, phenytoin, rifabutin, rifampin, and St. John\u2019s Wort
\nSubstrates CYP3A: using of Crizotinib should avoid with CYP3A substrates with narrow therapeutic indices including but not limited to alfentanil, cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus, and tacrolimus.<\/p>\n<\/div>\n

For more Oncology medicine, visit our SHOP<\/a><\/strong><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Crizocent(Crizotinib) is an anti-cancer medication that helps by kinase inhibition and prevents the growth and metastasis of cancerous cells in the human body.<\/p>\n

Crizocent 250 mg use for the treatment of cases who have locally advanced or metastatic non-small cell lung cancer (NSCLC). This is only use for lesions that are anaplastic lymphoma kinase (ALK)-positive or ROS 1 positive.<\/p>\n","protected":false},"featured_media":3024,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"mc_generic":[364],"brands":[405],"product_cat":[427,426],"product_tag":[286,237,438],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product\/1604"}],"collection":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/comments?post=1604"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/media\/3024"}],"wp:attachment":[{"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/media?parent=1604"}],"wp:term":[{"taxonomy":"mc_generic","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/mc_generic?post=1604"},{"taxonomy":"brands","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/brands?post=1604"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product_cat?post=1604"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/emergencydrug.com\/ar\/wp-json\/wp\/v2\/product_tag?post=1604"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}