Elbonix (Eltrombopag) 50 mg Tablet

Description

Elbonix (Eltrombopag ) is an orally bioavailable, small-molecule TPO-receptor agonist that interacts with the transmembrane domain of the human TPO-receptor and initiates signaling cascades that induce proliferation and differentiation from bone marrow progenitor cells. Elbonix is available in tablet form for oral administration.

Eltrombopag use to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. Eltrombopag recently approve (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.

Working Principle Eltrombopag

Eltrombopag is a thrombopoietin agonist. It works by stimulating the formation of new platelets in the blood. Platelets help to reduce or prevent bleeding.

Uses Elbonix

Eltrombopag is used for low platelet count due to ITP or HCV infection. That treat low platelet count due to chronic immune (idiopathic), thrombocytopenic purpura (ITP) or chronic hepatitis C virus (HCV) infection. Eltrombopag is also use to treat severe aplastic anemia.

Side Effects

Nausea, Diarrhoea, Upper respiratory tract infection, Vomiting, Increased liver enzymes, Muscle pain, Urinary tract infection

Thrombocytopenia

A condition in which there is a lower-than-normal number of platelets in the blood. It may result in easy bruising and excessive bleeding from wounds or bleeding in mucous membranes and other tissues.

Platelets (thrombocytes) are colorless blood cells that help blood clot. Platelets stop bleeding by clumping and forming plugs in blood vessel injuries.

A normal human platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. One common definition of thrombocytopenia requiring emergency treatment is a platelet count below 50,000 per microliter.

Signs and Symptoms

Thrombocytopenia signs and symptoms may include:

Easy or excessive bruising (purpura)
Superficial bleeding into the skin that appears as a rash of pinpoint-sized reddish-purple spots (petechiae), usually on the lower legs
Prolonged bleeding from cuts
Bleeding from your gums or nose
Blood in urine or stools
Unusually heavy menstrual flows
Fatigue
Enlarged spleen
Jaundice

Causes

Thrombocytopenia caused due to:

1. Increase platelet destruction due to-

Idiopathic thrombocytopenic purpura (ITP)
Sulfonamide antibiotics (Carbamazepine, Digoxin)
Heparin
Severe trauma

2. Decrease platelet production due to –

Chemotherapy
Viral infection (HCV, HIV)
Aplastic anemia
Bone marrow cancer
Long term alcohol intake

Visit our HIV related other product here

Manufacturer	: Beacon Pharma Ltd.
Indication	: increase platelet
Formulation	: Tablets
Strength	: 50 mg
Quantity	: 28 Tablets
Storage	: Below 30°C
Registrations	: Export Only

Elbonix (Eltrombopag) 50 MG – 28 Tablets

Description