Eudaxen (Diazoxide) 50 MG – 100 TABLETS

Description

Eudaxen tablet: Each tablet contains Diazoxide BP 50 mg.

Product Features

Diazoxide indication (Eudaxen): Eudaxen tablets are used orally in the treatment of intractable hypoglycemia.

Diazoxide is used orally to treat severe hypoglycemia with significant symptoms caused by a variety of conditions. These include idiopathic hypoglycemia in infancy, leucine-sensitive or unclassified hypoglycemia, and functional islet cell tumors (malignant or benign if inoperable). It is also recommended for cases involving extra-pancreatic neoplasms causing hypoglycemia, glycogen storage disease, and hypoglycemia of unknown cause. However, diazoxide may cause salt and water retention as a side effect.

Diazoxide Mechanism of Action

Diazoxide works as a diuretic by inhibiting chloride reabsorption in the kidney’s early distal tubule. This results in more sodium, chloride, and water being excreted in urine. Diazoxide, like thiazides, inhibits sodium transport in the kidneys, resulting in increased potassium excretion. Diazoxide’s mechanism of action for lowering blood pressure is unknown, but it may act on specific enzymes in muscle cells or affect a type of potassium channel in muscle tissue. Diazoxide’s antihyperglycemic action reduces pancreatic insulin release, most likely by opening potassium channels in beta cells.

Pharmacodynamics

Diazoxide activates potassium channels, allowing potassium ions to more easily pass through cell membranes. This causes nearby smooth muscles to relax. As a result, voltage-gated calcium ion channels are turned off, preventing the formation of an action potential.

Dosage and Administration

For both adults and children, start with an oral dose of 5mg/kg body weight divided into 2 or 3 equal doses every 24 hours to see how the patient responds. Then, adjust the dose as needed until symptoms and blood glucose levels improve.

It’s important to regularly check blood glucose levels during the initial days of treatment. The usual maintenance dose is 3-8mg/kg/day, split into two or three doses throughout the day. Patients with impaired kidney function may need lower doses. For children with leucine-sensitive hypoglycemia, consider a dosage range of 15-20mg/kg/day. In adults with islet-cell tumors producing excessive insulin, doses as high as 1,000mg per day have been used.

Diazoxide side effects: The adverse reactions are thrombocytopenia, pancreatitis, hypotension, diarrhea, heart failure etc.

Eudaxen Drug Interactions

Drugs potentiated by Diazoxide therapy include: oral diuretics, antihypertensive agents and anticoagulants.  Phenytoin levels should be monitored as increased dosage may be needed if administered concurrently with diazoxide.  The risk of hyperglycemia may be increased by concurrent administration of corticosteroids or estrogen-progestogen combinations.

Use in specific population

Studies in rats have shown that using Diazoxide during pregnancy can lead to increased fetal resorptions, delayed birth, and skeletal abnormalities in offspring. In rabbits, intravenous administration has resulted in skeletal and cardiac defects in fetuses. The drug can cross the placental barrier and cause damage to fetal pancreatic beta cells in animals. However, there isn’t enough data on its effects in pregnant women to determine its safety during pregnancy.

If Eudaxen is considered necessary during pregnancy, it should be limited to specific conditions in adults, and the potential benefits to the mother should be carefully weighed against possible risks to the fetus. Diazoxide Tablets should only be used in pregnant women if the mother’s life is at risk. Prolonged use of Diazoxide during pregnancy has been linked to newborn alopecia. Consult with your doctor. Contact us if you need any help and information about medicine

For nursing mothers, it’s unclear if Diazoxide passes into breast milk. Since many drugs can pass into breast milk and potentially harm nursing infants, mothers should decide whether to stop breastfeeding or discontinue the drug, considering its importance to their health.

Overdose

Taking too much Diazoxide can cause high blood sugar levels. If it’s severe, you might need insulin to bring it down. For less severe cases, oral medications for lowering blood sugar may help. Low blood pressure can be treated with fluids through an IV, and in serious situations, you might need drugs that mimic the actions of your sympathetic nervous system.