Palbonix (Palbociclib) 100 MG – 21 Capsules
Price: $220.00
Product Name: Palbonix
Generic Name: Palbociclib
Formulation: Capsules
Available Pack Size: 21’s in a bottle
Available Strengths: 100 mg
Manufacturer: Beacon Pharmaceuticals Ltd
Description
Medical Overview of Palbonix 100 MG
Introduction
Palbonix (Palbociclib) 100 mg is used to treat patients with certain types of breast cancer (estrogen receptor-positive, human epidermal growth factor receptor 2-negative), which have spread to other organs. It is given together with hormonal anticancer therapies. Palbonix 100 should be taken with food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months to see or feel the benefits but do not stop taking it unless your doctor tells you to. Some common side effects of this medicine include fatigue, hair loss, rash, vomiting, and diarrhea. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby increasing the susceptibility to infections. It is better to inform your doctor if you notice symptoms of infection like fever, chills, weakness, bleeding or bruising, and nose bleeding. It might also cause dizziness if it avoids driving or attention-seeking activities. Before taking it, tell your doctor if you have heart disease, liver or kidney problems, or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine, so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. Effective contraception by males and females during treatment is important to avoid pregnancy.
Uses of Palbonix (Palbociclib) 100 MG –
- Breast cancer
Side effects of Palbonix (Palbociclib) 100 MG –
- Fatigue
- Hair loss
- Rash
- Vomiting
- Diarrhea
- Nausea
- Decreased blood cells (red cells, white cells, and platelets)
- Infection
- Decreased appetite
- Fever
How to use Palbonix 100 MG –
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Palbonix 100 is to be taken with food.
How Palbonix 100 MG works –
Palbonix 100 is an anti-cancer medication. Cyclin-dependent kinase 4 and 6 (chemical messengers) are downstream of signaling pathways that lead to the proliferation of cells. This medicine works by inhibiting cyclin-dependent kinase 4 and 6, thus arresting the cancer cell cycle (cell growing process). It also targets the estrogen (hormone) receptor-positive breast cancer cells by disrupting the cell cycle.
- Take it with food, preferably at the same time every day
- If you forget to take medicine or vomit, skip the missed dose and follow a regular schedule. Do not take a double dose to make up the missed dose
- Use effective contraception methods to prevent pregnancy while taking this medicine
- It may cause dizziness. Avoid driving or any activity requiring mental focus until you know how it affects you
- You may be asked for regular blood tests while taking this medication. Inform your doctor if you notice symptoms of infection like fever, chills, and weakness
- Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding
- Do not stop taking the medication without talking to your doctor first.
Brief Description of Palbonix (Palbociclib) 100 MG
Indication
Indicated for hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, advanced breast cancer, in combination with an aromatase inhibitor as initial endocrine-based therapy in postmenopausal women, or with fulvestrant in women with disease progression endocrine therapy
Administration
Hard Capsule: Should be taken with food. Take at the same time each day. Swallow whole, do not chew/crush/open. Avoid grapefruit products.
Adult Dose
Oral Hormone receptor-positive, HER2-negative locally advanced carcinoma of the breast, Hormone receptor-positive, HER2-negative metastatic carcinoma of breast Adult: In combination with an aromatase inhibitor, or in combination with fulvestrant in women who have received prior endocrine therapy: 125 mg once daily for 21 days, followed by 7 days off, repeat every 28 days until disease progression or unacceptable toxicity. Dosage Modifications Dose reduction, dosing interruption, or discontinuation may be required according to individual safety or tolerability (refer to detailed product guidelines). Recommended dose reduction: 1st reduction: 100 mg once daily; 2nd reduction: 75 mg once daily; discontinue if dose reduction below 75 mg once daily is required. Hepatic impairment Mild or moderate (Child-Pugh A or B): No dose adjustment required. Severe (Child-Pugh C): Reduce dose to 75 mg/day for Days 1-21 of each 28-day cycle
Renal Dose
Renal impairment Mild, moderate, or severe (CrCl >15 mL/min): No dose adjustment required. Hemodialysis: Not studied.
Contraindication
Pregnancy and lactation.
Mode of Action
Palbociclib is a reversible, selective inhibitor of cyclin-dependent kinase (CDK) 4 and 6. Cyclin D1, CDK 4, and 6 are downstream of multiple signaling pathways which lead to cellular proliferation. Inhibition of CDK4/6 reduces the proliferation of breast cancer cell lines by blocking progression from G1 into the S phase of the cell cycle.
Precaution
Neutropenia was observed in clinical trials; febrile neutropenia was also reported; monitor CBC count before starting the drug and at the beginning of each cycle, as well as on Day 14 of the first 2 cycles, and as clinically indicated; dose interruption, dose reduction, or delay in starting treatment cycles is recommended for patients who develop grade 3 or 4 neutropenia.
Side Effect
The most common adverse reactions are:
- Nausea
- Vomiting
- Loss of appetite
- Diarrhea
- Tiredness
- Weakness
- Hair loss
- Mouth sores
- Numbness/tingling of arms/legs.
***The above information comes from the Internet. Please consult with a doctor for medical advice.
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