Palbociclib is an oral targeted cancer therapy that targets cyclin-dependent kinases 4 and 6 (CDK4/6), key proteins that regulate cell division. By blocking these kinases, palbociclib slows the growth and spread of cancer cells. It is initially used to treat hormone receptor-positive, HER2-negative advanced or metastatic breast cancer. Palbociclib is usually administered in combination with aromatase inhibitors or hormonal therapies such as fulvestrant, which increase their effectiveness in slowing cancer progression, particularly in postmenopausal women or patients whose cancer has progressed after prior endocrine therapy.

Palbociclib 125 mg

Advanced or Metastatic Breast Cancer:

In combination with an aromatase inhibitor (like letrozole) as the first-line treatment in postmenopausal women or men with hormone receptor-positive, HER2-negative advanced or metastatic breast cancer.

Breast Cancer with Disease Progression:

In combination with fulvestrant for hormone receptor-positive, HER2-negative advanced or metastatic breast cancer in patients whose disease has progressed following endocrine therapy.

Palbociclib 100 mg

Advanced or Metastatic Breast Cancer:

Used in combination with an aromatase inhibitor (such as letrozole) as initial treatment for hormone receptor-positive, HER2-negative advanced or metastatic breast cancer in postmenopausal people of all genders.

Breast Cancer with Disease Progression:

Used in combination with fulvestrant for hormone receptor-positive, HER2-negative advanced or metastatic breast cancer in patients whose disease has progressed after prior endocrine therapy.

Side Effects of  Palbociclib

Neutropenia: Low white blood cell count.

Nausea: Feeling of sickness or vomiting.

Fatigue: Extreme tiredness.

Diarrhea: Frequent loose stools.

Anemia: Low red blood cell count.

Mouth Sores: Ulcers or sores in the mouth.

Liver Function Changes: Elevated liver enzymes.

Warnings for Palbociclib

1.Risk of Neutropenia: Monitor blood counts regularly due to the potential for low white blood cell counts.

2.Liver Toxicity: Watch for signs of liver damage; monitor liver function tests.

3.Risk of Infection: Increased susceptibility to infections due to reduced immune function.

4.Pregnancy Category: Avoid use during pregnancy; potential harm to the fetus.

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