Axitinib comes as a tablet to take by mouth. It is usually taken with or without food two times a day. Take axitinib at around the same times every day, about 12 hours apart. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take axitinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole with a glass of water; do not split, chew, or crush them. If you vomit after taking Axinix, do not take another dose. Continue your regular dosing schedule.

Your doctor may start you on a low dose of axitinib and gradually increase your dose, not more than once every 2 weeks. This depends on how well the medication works for you and any side effects you might experience. Talk to your doctor about how you are feeling during your treatment. Continue to take axitinib even if you feel well. Do not stop taking axitinib without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

• Tell your doctor and pharmacist if you are allergic to axitinib, any other medications, or any of the ingredients in axitinib tablets. Ask your pharmacist for a list of the ingredients.
• Ask doctor if you have a wound that has not healed, or if you have or have ever had bleeding problems; blood clots; high blood pressure; a heart attack; diabetes; high cholesterol levels; bleeding in the stomach or intestines; brain cancer; a pulmonary embolism (blood clot in your lung); a stroke or mini stroke (TIA); or heart; liver; or thyroid disease.
• Tell your doctor if you are pregnant, plan to become pregnant, or if you plan to father a child. If you are female, you will have to take a pregnancy test before starting treatment and use birth control to prevent pregnancy during your treatment and for 1 week after your final dose. If you are male, you and your female partner should use birth control during your treatment and for 1 week after your final dose. Talk to your doctor about birth control methods that will work for you. If you or your partner becomes pregnant while taking axitinib, call your doctor. Axitinib may harm the fetus.
• If you are breastfeeding. You should not breastfeed during your treatment with axitinib and for 2 weeks after your final dose.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

Unless your doctor tells you otherwise, continue your normal diet.

If you miss a dose of Axinix, skip that dose and take your next dose at the regular time. Do not take a double dose to make up for a missed one.

Axinix may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• Diarrhea
• Decrease in appetite or ability to taste things
• Weight loss
• Nausea
• Vomiting
• Constipation
• Tiredness
• Weakness
• Change in the sound of your voice
• Redness, pain, numbness, tingling, or itching or peeling of the skin on your hands and feet
• Cough
• Joint or muscle pain
• Mouth sores
• Stomach pain
• Headache
• Dizziness
• Rash
• Itching
• Dry skin
• Fast heart beat
• Hair loss
• Hemorrhoids

Serious side effects

If you experience any of these symptoms, call your doctor immediately or get emergency medical help:

• Severe stomach pain
• Shortness of breath
• Swelling in hands or feet
• Unusual bleeding or bruising
• Black and tarry stools
• Red blood in stools
• Bloody vomit
• Vomiting material that looks like coffee grounds
• Chest pain or pressure
• Pain in the arms, back, neck, or jaw
• Swelling, tenderness, warmth, or redness of a leg
• Numbness or weakness of face, arm, or leg (especially on one side of the body)
• Confusion, trouble speaking or understanding
• Trouble seeing in one or both eyes
• Trouble walking, dizziness, loss of balance or coordination
• Severe headache with no known cause

Axinix may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community.

Symptoms of overdose

• Dizziness
• Seizures
• Coughing up blood

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body’s response to Axinix. Your doctor will also check your blood pressure regularly during your treatment with axitinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

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