Description
Product Features:
| Product Name | : Capixet |
| Generic Name | : Capecitabine |
| Manufacturer | : Everest Pharma Ltd |
| Indication | : Breast & Colorectal Cancer |
| Formulation | : Tablet |
| Strength | : 500 mg |
| Quantity | : 14 Tablets |
| Storage | : Below 30°C |
| Registrations | : Export Only |
INDICATION:
1. Colorectal cancer: Adjuvant treatment of stage III colon cancer and treatment of metastatic colorectal cancer.
2. Breast cancer: Treatment of metastatic breast cancer.
3. Gastric cancer: It is used in combination with other cancer treatments to treat gastric cancer.
4. Other Cancers: It can also be used to treat esophageal, and gastroesophageal junction cancers.
HOW IT WORKS:
Capecitabine is a prodrug, which means that it is converted to its active form (5-fluorouracil or 5-FU) in the body. 5-FU inhibits the synthesis of DNA and RNA, thereby obstructing the proliferation and dissemination of cancer cells.
DOSAGE AND ADMINISTRATION
1. Swallow Capixet 500 mg with water for 30 minutes after the meal.
2. Monotherapy: 1250mg/m2-BIDPO for 2 weeks then, 1 week pause (cycles 3 wks).
3. Total 6 month (8 cycles) of adjuvant treatment is advised.
4. When used in combination with Docetaxel, the recommended dose of Capecitabine is 1250 mg/m2 PO bid for 2 weeks followed by 1 week rest with Docetaxel given as a 1 hour IV infusion every 3 weeks at 75 mg/m2.
5. The dosing of Capixet 500 mg for individual patient management may require adjustment.
6. In patients with moderate renal impairment, Capecitabine dose should be decreased by 25%
SIDE EFFECTS:
1. Gastrointestinal issues: Nausea, vomiting, diarrhea, stomach pain.
2. Hand-foot syndrome: Redness, swelling, and pain on the palms and soles.
3. Fatigue.
4. Loss of appetite.
5. Mouth sores.
6. Low blood cell counts (increased risk of infections, anemia, or bleeding).
7. Diarrhea
8. Nausea and vomiting
9. Decreased blood cell counts.
PRECAUTIONS:
1. Tell your doctor if you have kidney or liver problems, because your dose may need to be changed.
2. Pregnant and breastfeeding women must not take Capixet because it has harmful effects on their embryo and infant.
3. Capixet 500 mg can impair fertility and cause birth defects; therefore effective contraception should be used during treatment.
DRUG INTERAACTIONS:
Combining some medications runs the danger of harmful drug interactions. When Capecitabine is taken with calcium folinate or phenytoin, for instance, it can change the medicine levels in your blood and raise your adverse effect risk. Taking warfarin and Capecitabine combined increases your risk of bleeding.
USE IN PREGNANCY AND LACTATION:
Pregnancy Category D Animal reproduction studies have shown an adverse effect on the fetus, but there are no adequate and well controlled studies in humans. If this drug is used during pregnancy or if the patient becomes pregnant while receiving Capecitabine, the patient should be advised of the potential risk to a fetus. Women of childbearing age should be warned not to get pregnant while receiving Capecitabine.
It is unknown whether the drug or its metabolites are excreted in human milk. Given the potential for severe adverse reactions in nursing neonates from Capixet 500 mg, it is necessary to determine whether to discontinue nursing or the drug, while considering the drug’s significance to the mother.
OVERDOSE:
Acute overdose manifestations would inc ude nausea, vomiting, diarrhea, gastrointestinal irritation and beeding, and bone marrow depression. Specific medications of choice in overdose should include the general supportive medical therapies indicated for the correction of the clinical syndromes that present. There is no documented clinical experience with the use of dia ysis in the treatment of Capixet 500 mg overdose, but may be useful in decreasing the circulating concentration of 51 -DFUR, a ow-molecu ar-weight metabolite of the parent compound.
KEY POINTS:
1. Capixet must be used under an oncologist’s guidance, as it is a prescription medication.
2. You should always adhere to your doctor’s instructions closely, and with any side effects, be certain to inform your doctor straight away.
3. Always take Capixet as prescribed by your oncologist and report any severe or unusual side effects immediately.
Disclaimer: This information is provided solely for educational reasons and should not be considered medical advice. Always consult with your doctor or healthcare professional before taking any drug.
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