Description

Olanib (Olaparib) is an FDA-approved targeted therapy for cancer. It is a PARP inhibitor, inhibiting poly ADP ribose polymerase, an enzyme involved in DNA repair. It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations, which include some ovarian, breast and prostate cancers.

 

Olaparib Uses For Patients

Olanib 50mg capsules use to treat advanced ovarian cancer (with deleterious germline brca mutated (gBRCAm) as detected by an FDA-approved test) who have treated with three or more prior lines of chemotherapy. Furthermore use to treat her2-negative metastatic breast cancer (with deleterious or suspected gBRCAm), who treat with chemotherapy. Generic olaparib likes a targeted therapy. It is a poly (ADP-ribose) polymerase (PARP) enzyme inhibitor, including parp1, parp2, and parp3. PARP enzymes involve in DNA transcription, cell cycle regulation, and DNA repair. olaparib is a potent oral PARP inhibitor which induces synthetic lethality in brca 1/2 deficient tumor cells through the formation of double-stranded DNA breaks which cannot accurately repair, which leads to disruption of cellular homeostasis and cell death.

 

Side Effect Causes

Most people do not experience all of the side effects listed. Side effects are often predictable in terms of their onset and duration. There are many options to help minimize or prevent side effects. There is no relationship between the presence or severity of side effects and the effectiveness of the medication.

 

Nursing Mothers

Olanib (Olaparib) do not known to excrete in human milk. Because many drugs excrete in human milk and because of the potential for serious adverse reactions in nursing infants from , a decision made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

 

Populations With Reproductive Potential

Pregnancy testing recommend for females of reproductive potential prior to initiating treatment with Olanib. It can cause fetal harm when administered to a pregnant woman. Advise females of reproductive potential to use highly effective contraception. during treatment with  and for at least 6 months following the last dose.

 

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