Description

Tofacinix (Tofacitinib) is a Janus Kinase (JAK) inhibitor JAKs is an intracellular enzyme that transmits signals arising from cytokine or growth factor-receptor reaction on the cellular membrane to influence cellular processes hematopoiesis and immune cell function. Tofacinix modulates the signaling pathway at the point of JAKs, removing the phosphorylation and activation of STATs.

Instruction About Tofacitinib

Before you start treatment, your doctor may perform tests to make sure you do not have an infection. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

A safe dose of tofacitinib is not the same for all conditions. Avoid medication errors by using only the form and strength your doctor prescribes. You may take tofacitinib with or without food.

Tofacitinib doses are based on weight in children and teenagers. Your child’s dose needs may change if the child gains or loses weight.

Swallow the extended-release tablet whole and do not crush, chew, or break it.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

If you’ve ever had shingles (herpes zoster) or hepatitis B or C, using tofacitinib can cause these viruses to become active or get worse.

Before taking this medicine

Tell your doctor if you have ever had:

• Liver disease (especially hepatitis B or C);
• Heart problems (especially if you are 50 or older);
• Lung disease;
• A blood clot;
• A chronic infection;
• HIV, or a weak immune system;
• A stomach or intestinal problem such as diverticulitis or an ulcer;
• Kidney disease (or if you are on dialysis);
• Diabetes; or
• If you are scheduled to receive any vaccine.

Taking Tofacinix at too high a dose may increase the risk of death in people with rheumatoid arthritis who are 50 and older and have at least 1 risk for heart disease. This includes high blood pressure, high cholesterol, diabetes, smoking, being overweight, or having a family history of heart disease. Talk to your doctor about your specific risk, and take only your recommended dose.

Tell your doctor if you have ever had tuberculosis or if anyone in your household has tuberculosis. Also tell your doctor if you have recently traveled. Tuberculosis and some fungal infections are more common in certain parts of the world, and you may have been exposed during travel.

Precaution

Using Tofacinix may increase your risk of developing certain cancers, such as lymphoma or skin cancer. Ask your doctor about this risk.

It is not known whether tofacitinib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Tofacitinib may affect your ability to have children during treatment and in the future.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of tofacitinib on the baby.

Do not breastfeed while you are using this medicine, and for at least 18 hours after your last dose (36 hours if you take extended-release tablets). If you use a breast pump during this time, do not feed the milk to your baby.

Do not give this medicine to a child without medical advice. The extended-release tablets are not approved for use by anyone younger than 18 years old.

Miss a dose

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Avoid while taking tofacitinib

Do not receive a “live” vaccine while using tofacitinib, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

Tofacinix side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some people taking high doses of tofacitinib have developed serious or fatal blood clots. Stop taking Tofacinix and seek emergency medical attention if you have:

• sudden shortness of breath;
• pain while breathing;
• cough with pink or red mucus;
• pain in your chest or back;
• clammy or blue-colored skin, heavy sweating; or
• pain, swelling, or redness in an arm or a leg.

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