Baricitinib Price & Cost and Brands

Baricitinib medication is an oral Janus kinase (JAK) inhibitor used primarily to treat moderate to severe rheumatoid arthritis (RA) in adults who have not responded to other treatments. It works by interfering with inflammatory pathways to reduce pain, swelling and joint damage. In addition to its RA use, it has shown promise as a treatment for alopecia areata, an autoimmune disorder in which the immune system attacks hair follicles, causing sudden, ingrown hairs to fall out. The drug is also being investigated for other conditions, such as COVID-19.

Available Brands and Baricitinib Price List:

The Brand name of the Baricitinib Generic:

The brand name Olumiant markets Baricitinib. Developed by Eli Lilly and Company, Olumiant is the primary globally available brand name for baricitinib. The drug comes in different dosages, primarily 2 mg and 4 mg tablets, and is taken once daily.
Now most companies have been producing this generic with different brands’ names. Like, Beacon Pharmaceuticals Limited manufactures Baricinix. And General Pharmaceuticals Limited manufactures Barigen.

Baricitinib 4 mg

Baricitinib 4 mg is a drug used to treat severe alopecia areata, an autoimmune disorder that causes hair loss in patches. By inhibiting the Janus kinase (JAK) enzyme, It helps reduce inflammation and prevents the immune system from attacking hair follicles. Clinical studies have shown that a daily dose of 4 mg can significantly promote hair regrowth. Although it is generally well tolerated, possible side effects include respiratory infections, increased liver enzymes, and high cholesterol. The drug also carries warnings of serious risks, such as infection and cardiovascular events.

Baricitinib 2 mg

Baricitinib 2 mg is a low-dose version of the drug used to treat moderate to severe rheumatoid arthritis in adults, especially when other treatments have not worked well. This dose is often used in step-up treatments or for patients who are more sensitive to the drug. It helps reduce inflammation by targeting specific pathways, relieving joint pain and swelling, and improving daily life and overall well-being. Doctors adjust the dosage based on how well the patient responds and tolerates the medication with regular check-ups to ensure optimal results and minimize side effects.

Baricitinib cost

The cost of baricitinib can vary widely based on several factors, including country of purchase, insurance coverage, dosage, and pharmacy. In the United States, a 30-day supply of 2 mg baricitinib tablets can cost about $100 to $3,000 without insurance. A 30-day supply of 4 mg baricitinib tablets costs about $200 to $6,000 if you pay out-of-pocket without insurance.

Baricitinib Dose & Administration

Take Baricitinib orally in tablet form. Start with a usual dose of 2 mg once daily, increasing to 4 mg if necessary based on patient response and tolerability. Take the medicine at the same time every day, with or without food. Follow your doctor’s instructions regarding dose adjustments and attend regular follow-up appointments to monitor treatment effectiveness and possible side effects. If you miss a dose, take it as soon as possible unless it is almost time for the next dose. In that case, omit the missed dose. Always consult a healthcare provider for specific medical advice tailored to your individual health needs.

Mechanism of action (moa)

Baricitinib is a Janus kinase (JAK) inhibitor that targets the JAK1 and JAK2 enzymes. By binding to these enzymes, It blocks their activation and subsequent signaling of inflammatory cytokines. This inhibition disrupts the JAK-STAT pathway, which is crucial for transmitting signals from various cytokines involved in immune and inflammatory responses. As a result, baricitinib helps reduce inflammation and modulate the immune system, relieving symptoms of conditions such as rheumatoid arthritis, alopecia areata and severe COVID-19.

Baricitinib chemical structure (C16 H17 N7 O2) is complex. It features a pyrazole ring and a pyrimidine ring. The structure includes:

• Pyrazole ring: A five-membered ring with two adjacent nitrogen atoms.
• Pyrimidine ring: A six-membered ring with two nitrogen atoms.
• Phenyl group: A benzene ring attached to the pyrazole ring.

For a detailed chemical structure, refer to a chemical database or scientific literature where the structure is illustrated.

Side Effects

1. Infections
2. Gastrointestinal Issues
3. Hematologic Effects
4. Elevated Lipids
5. Liver Function
6. Risk of Blood Clots
7. Allergic Reactions
8. Gastrointestinal Perforation

Common side effects

1. Upper Respiratory Tract Infections
2. Nausea
3. Headache
4. Increased Blood Lipids
5. Increased Liver Enzymes
6. Herpes Zoster
7. Hyperlipidemia
8. Thrombocytosis
9. Allergic Reactions
10. Gastrointestinal Symptoms

Warning

Be aware of some significant precautions when using Baricitinib. It can increase the risk of serious infections such as tuberculosis, as well as other bacterial, fungal, or viral infections because it affects the immune system. You may face a potential risk of blood clots, which can cause serious problems such as deep vein thrombosis or pulmonary embolism. Long-term use of this drug may raise the risk of certain cancers, including lymphoma, which can be worrisome. You may see changes in liver enzyme levels and increases in cholesterol and triglycerides. Although rare, you could face a risk of serious gastrointestinal problems such as perforation. Note that there may be a high chance of heart-related problems. Use baricitinib with extra caution if you are pregnant or breastfeeding.

Attend regular check-ups and have open discussions with your healthcare provider to effectively manage these risks and ensure the medication is right for you.

During Pregnancy

Do not use Baricitinib during pregnancy because it may pose risks to the fetus, such as birth defects and toxicity observed in animal studies. If you are of childbearing age, use effective contraception while taking this medication and for at least a week after your last dose. There isn’t enough information on how it affects pregnant women or whether it passes into breast milk. If you are pregnant or planning to become pregnant, talk to your healthcare provider for personalized advice.

Baricitinib prescribing information

FAQ Section of Baricitinib Generic

1. How much does baricitinib cost?

Ans: The cost of baricitinib can vary widely based on location, insurance coverage, and pharmacy. In the United States, the price for a 30-day supply (2 mg or 4 mg tablets) typically ranges from $100 to $6,000. Prices can differ based on the pharmacy and location.

2. Where to buy baricitinib?

Ans: You can purchase Baricitinib at most major pharmacies, including CVS, Walgreens, and Walmart, as well as online pharmacies. You will need a prescription from a healthcare provider.

3. Who manufactures baricitinib?

Ans: Baricitinib is manufactured by Eli Lilly and Company. Eli Lilly and Company is headquartered in Indianapolis, Indiana, USA.

4. What is the name of the baricitinib brand?

Ans: The brand name for baricitinib is Olumiant.

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