Description
Osimert 80 mg is an oral medicine containing osimertinib, an EGFR tyrosine kinase inhibitor used in the treatment of certain EGFR-mutated non-small cell lung cancer (NSCLC). Osimert works by targeting abnormal EGFR signaling that can contribute to cancer cell growth. The 80 mg strength is used in several approved treatment settings, including certain patients with EGFR exon 19 deletions or exon 21 L858R mutations.
Product Features of Osimert 80 MG (Osimertinib):
| Product Name | : Osimert |
| Generic Name | : Osimertinib |
| Manufacturer | : Everest Pharma Ltd |
| Indication | : Non-small cell lung cancer |
| Formulation | : Tablet |
| Strength | : 80 mg |
| Quantity | : 30 Tablets |
| Storage | : Between 20°C to 25°C |
| Registrations | : Export Only |
Osimert 80 mg price in USA: $80.00 per pack
Osimert 80 mg Tablet: Each film-coated tablet contains Osimertinib mesylate INN 80 mg.
Pharmacology
It is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI ) that binds to certain mutant forms of EGFR (T790M, L858R, and exon 19 deletion) that predominate in non-small cell lung cancer (NSCLC) tumor following treatment with first-line EGFR-TKIs. As a third-generation tyrosine kinase inhibitor, Osimert is specific for the gate-keeper T790M mutation which increases ATP binding activity to EGFR and results in poor prognosis for late-stage disease. Furthermore, it has shown to spare wild-type EGFR during therapy, thereby reducing non-specific binding and limiting toxicity.
Osimert Dosage
The recommended dose of Osimert 80 mg is once a day until disease progression or unacceptable toxicity. It can taken with or without food. If a dose of Osimertinib missed, do not make up the missed dose and take the next dose as scheduled.
Administration
Administration To Patients Who Have Difficulty Swallowing Solids: Disperse tablet in 60 ml (2 ounces) of non-carbonated water only. Stir until tablet is dispersed into small pieces (the tablet will not completely dissolve) and swallow immediately. Do not crush, heat, or ultrasonicate during preparation. Rinse the container with 120 ml to 240 ml (4 to 8 ounces of) water and immediately drink.
If administration via nasogastric tube require, disperse the tablet as above in 15 ml of non-carbonated water, and then use an additional 15 ml of water to transfer any residues to the syringe. The resulting 30 ml liquid administer as per the nasogastric tube instructions with appropriate water flushes (approximately 30 ml).
Interaction
Strong CYP3A4 Inducers: If concurrent use is unavoidable, increase Osimert dosage to 160 mg daily when Coad ministering with a strong CYP3A inducer. Resume Osimert at 80 mg 3 weeks after discontinuation of the strong CYP3A4 inducer
Osimert 80 MG Side Effects
Common side effects are Interstitial Lung Disease or Pneumonitis, QTc Interval Prolongation, Cardiomyopathy, Keratitis
Pregnancy & Lactation
Use in Pregnancy: There are no or limited amount of data from the use of it in pregnant women. Studies in animals have shown reproductive toxicity. Based on its mechanism of action and preclinical data, it may cause foetal harm when administered to a pregnant woman. Administration of this generic medicine to pregnant rats associate with embryolethality, reduced foetal growth and neonatal death at exposures similar to what expected in humans. Osimertinib is not recommended during pregnancy and in women of childbearing potential not using contraception.
Use in Lactation: It is not known whether this generic medicine or its metabolites excrete in human milk. Administration to rats during gestation and early lactation associate with adverse effects, including reduce growth rates and neonatal death. There is insufficient information on the excretion of this type of generic medicine or its metabolites in animal milk. A risk to the suckling child cannot excluded. Breast-feeding should discontinue during treatment with Osimertinib.
Fertility: There are no data on the effect of Osimertinib on human fertility. Results from animal studies have shown that Osimertinib has effects on male and female reproductive organs and could impair fertility
Therapeutic Class:
Cytotoxic Chemotherapy
Real Reddit User Experience ( Osimert 80 mg Review)
A Reddit user shared that his mother, diagnosed with Stage IV non‑small cell lung cancer (NSCLC) with brain metastasis, was prescribed Osimertinib 80 mg as part of targeted therapy. Due to the extremely high cost of the branded version (AstraZeneca, INR 1.25 lakh/month), the family looked for affordable alternatives.
After failing to source Tagrix from Beacon Pharmaceuticals, they were connected to a supplier which is the Emergencydrug.com of Osimert 80 mg from Bangladesh.
His mother has now been using Osimert for over 6 months. PET-scan results were encouraging – lung lesions reduced by almost half at 3 months, and remained stable by month 6.
Proven Result Summary:
Osimert 80 mg proved to be an effective, affordable alternative to Tagrisso/Tagrix, offering strong clinical response and stable disease in a real-world Stage IV NSCLC case.
Why Buy from Us :
If you are looking to buy Osimert 80 mg (osimertinib), visit Emergency Drug’s Osimert 80 mg product page for product and ordering information. Osimertinib is a prescription cancer medicine, so treatment should be used only under the direction of a qualified healthcare professional with a valid prescription.
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Osimert 80 MG (Osimertinib)Tablet | Buy Worldwide Now
Get the best deal on Osimert 80 mg (Osimertinib). Learn uses, side effects, dosages, and many more. Price: $80.00 per pack. Add to cart now!
Product Brand: Osimert 80 MG Tablet
Product Currency: USD
Product Price: 80.00
Product In-Stock: InStock
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