Description

Descriptions 

Venetoclax is a prescription medicine use:

• to treat adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
• in combination with azacitidine, or decitabine, or low-dose cytarabine to treat adults with newly-diagnosed acute myeloid leukemia (AML) who:
• • are 75 years of age or older, or
  • have other medical conditions that prevent the use of standard chemotherapy.

It approve base on response rates. Continued approval for this use may depend on the results of an ongoing study to find out how works over a longer period of time.

It is not known safe and effective in children.

Indications

Venetoclax is a small molecule type of targeted therapy. It is a pill that promotes apoptosis, a common way by which cells die. It does this by binding to BCL-2, an anti-apoptotic protein. Overexpression of BCL-2 has been demonstrated in CLL cells where it mediates tumor cell survival and has been associated with resistance to chemotherapies. It helps restore the process of apoptosis by binding directly to the BCL-2 protein, displacing pro-apoptotic proteins. It blocks an important pathway that promotes cell survival in tumor cells that overexpress BCL-2, so capsule causes cells to die (pro-apoptotic).

Dosage & Administration

• It is a tablet, taken by mouth.
• It take orally once daily with a meal and water.
• Dosage adjusted base on side effects.
• Take exactly as prescribe.
• Swallow tablets whole. Do not crush, chew, break or dissolve tablets.
• Do not change your dose or stop.

The amount of that medicine you will receive depends on many factors, your general health or other health problems, and the type of cancer or condition become treated.

Side Effects

Important things to remember about the side effects of venetoclax:

Most people do not experience all of the side effects listed.
Side effects are often predictable in terms of their onset and duration.
Side effects usually reversible and often improve or go away after treatment stop.
There are many options to help minimize or prevent side effects.
There is no relationship between the presence or severity of side effects and the effectiveness of the medication.

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