elbonix-eltrombopag-50mg

Elbonix (Eltrombopag) 50 MG

Eltrombopag

Price: $230.00

Eltrombopag use to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. Eltrombopag recently approve (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.

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Description

Elbonix (Eltrombopag ) is an orally bioavailable, small-molecule TPO-receptor agonist that interacts with the transmembrane domain of the human TPO-receptor and initiates signaling cascades that induce proliferation and differentiation from bone marrow progenitor cells. Elbonix is available in tablet form for oral administration.

Product Features:

Product Name : Elbonix
Generic Name : Eltrombopag Olamine
Formulation : Tablet
Available Pack Size : 4×7 ’s  and 4×7’s
Available Strengths : 25 mg and 50 mg
Registrations : Bangladesh
Category : Hematopoietic

 

Working Principle Eltrombopag  

Eltrombopag is a thrombopoietin agonist. It works by stimulating the formation of new platelets in the blood. Platelets help to reduce or prevent bleeding.

Uses Elbonix 

Eltrombopag is used for low platelet count due to ITP or HCV infection. That treat low platelet count due to chronic immune (idiopathic), thrombocytopenic purpura (ITP) or chronic hepatitis C virus (HCV) infection. Eltrombopag is also use to treat severe aplastic anemia.

Side Effects 

Nausea, Diarrhoea, Upper respiratory tract infection, Vomiting, Increased liver enzymes, Muscle pain, Urinary tract infection


Thrombocytopenia

A condition in which there is a lower-than-normal number of platelets in the blood. It may result in easy bruising and excessive bleeding from wounds or bleeding in mucous membranes and other tissues.

Platelets (thrombocytes) are colorless blood cells that help blood clot. Platelets stop bleeding by clumping and forming plugs in blood vessel injuries.

A normal human platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. One common definition of thrombocytopenia requiring emergency treatment is a platelet count below 50,000 per microliter.

Signs and Symptoms

Thrombocytopenia signs and symptoms may include:

  •  Easy or excessive bruising (purpura)
  •  Superficial bleeding into the skin that appears as a rash of pinpoint-sized reddish-purple spots (petechiae), usually on the lower legs
  •  Prolonged bleeding from cuts
  •  Bleeding from your gums or nose
  •  Blood in urine or stools
  •  Unusually heavy menstrual flows
  •  Fatigue
  •  Enlarged spleen
  •  Jaundice

Causes 

Thrombocytopenia caused due to:

1. Increase platelet destruction due to-

  •  Idiopathic thrombocytopenic purpura (ITP)
  •  Sulfonamide antibiotics (Carbamazepine, Digoxin)
  •  Heparin
  •  Severe trauma

2. Decrease platelet production due to –

  •  Chemotherapy
  •  Viral infection (HCV, HIV)
  •  Aplastic anemia
  •  Bone marrow cancer
  •  Long term alcohol intake

 

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