Description
Elopag (Eltrombopag ) is an orally bioavailable, small-molecule TPO-receptor agonist that reaction with the transmembrane domain of the human TPO-receptor and initiates signaling cascades that induce proliferation and differentiation from bone marrow progenitor cells. Elopag is available in tablet form for oral administration.
- Improves chronic ITP & SAA effectively.
- Effective in chronic hepatitis C related thrombocytopenia.
- Increases & maintains platelet counts.
Product Name | : Elopag |
Generic Name | : Eltrombopag Olamine |
Formulation | : Tablet |
Available Pack Size | : 4×7 ’s and 4×7’s |
Available Strengths | : 25 mg and 50 mg |
Registrations | : Bangladesh |
Category | : Hematopoietic |
Working Principle Elopag
Uses Elopag
Side Effects
Thrombocytopenia
A condition in which there is a lower-than-normal number of platelets in the blood. It may result in easy bruising and excessive bleeding from wounds or bleeding in mucous membranes and other tissues.
Platelets (thrombocytes) are colorless blood cells that help blood clot. Platelets stop bleeding by clumping and forming plugs in blood vessel injuries.
A normal human platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. One common definition of thrombocytopenia requiring emergency treatment is a platelet count below 50,000 per microliter.
Signs and Symptoms
Thrombocytopenia signs and symptoms may include:
- Easy or excessive bruising (purpura).
- Superficial bleeding into the skin that appears as a rash of pinpoint-sized reddish-purple spots (petechiae), usually on the lower legs.
- Prolonged bleeding from cuts.
- Bleeding from your gums or nose.
- Blood in urine or stools.
- Unusually heavy menstrual flows.
- Fatigue.
- Enlarged spleen.
- Jaundice.
Causes
Thrombocytopenia caused due to:
1. Increase platelet destruction due to reason-
- Idiopathic thrombocytopenic purpura (ITP).
- Sulfonamide antibiotics (Carbamazepine, Digoxin).
- Heparin.
- Severe trauma.
2. Decrease platelet production due to reason –
- Chemotherapy.
- Viral infection (HCV, HIV).
- Aplastic anemia.
- Bone marrow cancer.
- Long term alcohol intake.
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