Sofosbuvir-Velpatasvir

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Sofosbuvir Velpatasvir is used to treat chronic hepatitis C virus (HCV) infection.

 

Sofosbuvir Velpatasvir is a potent antiviral drug used to treat chronic hepatitis C virus (HCV) infection. This combination therapy combines two active ingredients: sofosbuvir, a nucleotide analog polymerase inhibitor that blocks replication of viral RNA, and velpatasvir, an NS5A inhibitor that disrupts viral assembly and replication. Effective across all six major HCV genotypes, Sofosbuvir/Velpatasvir serves as a versatile and pan-genotypic treatment option. Sofosbuvir-Velpatasvir offers a convenient once-daily oral therapy that has revolutionized the treatment landscape, leading to high rates of sustained virologic response (SVR), which is considered a definitive cure for hepatitis C in the majority of patients.

 

Sofosbuvir 400 mg

  • Chronic HCV Infection: Effective against all major HCV genotypes (1-6) when used in combination with other antiviral agents.
  • HCV with Cirrhosis: Suitable for both compensated and decompensated cirrhosis.
  • HCV/HIV-1 Co-infection: Used in patients co-infected with HCV and HIV-1.

>> Sofosbuvir is not used alone, it is always combined with Velpatasvir.

 

Velpatasvir 100 mg

  • Chronic HCV Infection: Effective across all genotypes.
  • HCV with Cirrhosis: Used in patients with compensated or decompensated cirrhosis.
  • HCV/HIV-1 Co-infection: Treats patients co-infected with HCV and HIV-1.

>> Velpatasvir is not used alone; it is always combined with Sofosbuvir.

 

Side Effects of Sofosbuvir and Velpatasvir

  • Headache
  • Fatigue
  • Nausea
  • Diarrhea
  • Insomnia
  • Anemia (low red blood cell count)
  • Elevated Liver Enzymes
  • Dizziness
  • Weakness
  • Rash
  • Muscle pain
  • Low blood pressure
  • Liver problems
  • Shortness of breath
  • Bradycardia (slow heart rate)

 

Warnings of Sofosbuvir Velpatasvir

1. Risk of Hepatitis B Reactivation: Patients with a history of hepatitis B virus (HBV) infection should be monitored for HBV reactivation.

2. Liver Function Monitoring: Regular monitoring of liver function is recommended, especially in patients with cirrhosis or liver impairment.

3. Drug Interactions: Potential interactions with other medications, including antiretrovirals and certain anticonvulsants, may affect efficacy or increase side effects.

4. Pregnancy Category: Use with caution during pregnancy, and effective contraception is advised as safety during pregnancy has not been established.

 

Available Brands and Pricing List:

Brand Name
Manufacture
Quantity
Sofosbuvir Velpatasvir cost in USD
Panovir

Incepta Pharma

28 Tablets

$85

Sofosvel

Beacon Pharma

28 Tablets

$120

Velpanex

Everest Pharma

28 Tablets

$85

 

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