Lenvatinib Generic: Mechanism of Action, Uses and More

lenvatinib mechanism of action

What is Lenvatinib

Lenvatinib is an oral dose, which is generally used for certain types of cancer. In addition, it works with receptor tyrosine kinase (RTK) inhibitors, targeting various proteins involved in cancer cell growth.

 

Lenvatinib Mechanism of Action or How Does Lenvatinib Work?

 

Lenvatinib works as a multi-targeted tyrosine kinase inhibitor (TKI). In many cancers, these pathways become overactive, leading to uncontrolled tumor growth. Inhibiting these critical enzymes, lenvatinib disrupts signaling processes that promote cancer cell proliferation and survival.

 

  • Blocking Platelet-Derived Growth Factor Receptors (PDGFR):

PDGFR promotes cell growth and blood vessel formation. By targeting PDGFR, lenvatinib further inhibited tumor growth and angiogenesis. As a result, it adds another layer to the multifaceted approach to cancer treatment.

 

  • Inhibition of RET Proto-Oncogene:

In certain types of thyroid cancer, the RET proto-oncogene critically drives tumor growth. Lenvatinib effectively treats these specific malignancies by inhibiting RET.

Dosage Forms and Strengths

Lenvatinib is available in two dosage strengths:

  • Lenvatinib 4mg capsules
  • Lenvatinib 10mg capsules

The flexibility in dosing allows for adjustments based on individual patient needs and tolerance.

 

Drug Interactions:

Lenvatinib, a potent multi-kinase inhibitor, is used to treat a variety of cancers. This section outlines known drug interactions associated with lenvatinib and effectively manages these interactions.

 

Administration and Dosing

(1)Dosing Recommendations

  • Thyroid Cancer: The initial dose is generally once per day.
  • Renal Cell Carcinoma: The dose is Lenvatinib taken once every day.
  • Hepatocellular Carcinoma: The initial dose depends on the patient’s body weight. Patients weighing 60kg or more should receive one time daily.

 

(2)Administration Guidelines :

Healthcare professionals provide specific instructions for administering lenvatinib. Lenvatinib can be prescribed at different doses and frequencies depending on individual treatment needs. Close monitoring and open communication with healthcare providers help ensure effective and safe administration of lenvatinib for optimal treatment outcomes.

 

Lenvatinib Uses and Used For

Lenvatinib is a multi-kinase inhibitor usage to treat various types of cancer. It works by inhibiting specific enzymes that contribute to the growth and spread of cancer cells. Here are some common uses of Lenvatinib:

 

  1. Thyroid Cancer:
    • Indication: Treat differentiated thyroid cancer (DTC) which is refractory to radioactive iodine treatment.
    • Administration: It is generally administere orally once a day.
  2. Renal Cell Carcinoma (RCC):
    • Indication: Lenvatinib is use in combination with everolimus to treat advanced renal cell carcinoma after one prior anti-angiogenic therapy.
    • Administration: Taken orally once per day, lenvatinib requires dosage adjustments based on tolerability and patient response. Consequently, healthcare providers closely monitor patients to optimize the treatment’s effectiveness and minimize side effects.
  3. Hepatocellular Carcinoma (HCC):
    • Indication: Lenvatinib is used as a first-line treatment for patients with unresectable hepatocellular carcinoma.
    • Administration: Taken orally once a day, with dose adjustments based on body weight and patient tolerance.

 

FDA Approval

The FDA approved lenvatinib for use in DTC in 2015, followed by approvals for RCC, HCC, and endometrial cancer. These approvals are based on extensive clinical trials demonstrating its efficacy and safety.

 

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