Description
Introduction of Xeljanz
Xeljanz generic name is tofacitinib, is an oral medication used to treat various inflammatory conditions. It belongs to a class of drugs called Janus kinase (JAK) inhibitors, which play a crucial role in managing autoimmune diseases by modulating the immune system’s activity.
Mechanism of Action
Xeljanz functions by inhibiting Janus kinases, enzymes that play a crucial role in the signaling pathways of numerous cytokines and growth factors essential for blood cell formation and immune function. By blocking these pathways, it reduces the inflammatory response, thereby alleviating symptoms associated with autoimmune conditions.
Xeljanz used for
It is approved for treating several conditions:
- Rheumatoid Arthritis (RA):
It is indicated for adults with moderate to severe active rheumatoid arthritis (RA) who have not responded adequately to or cannot tolerate methotrexate. Patients can use it alone or in combination with methotrexate or other non-biologic disease-modifying antirheumatic drugs (DMARDs).
- Psoriatic Arthritis (PsA):
Approved for adults with active psoriatic arthritis (PsA) who have not responded adequately to or cannot tolerate methotrexate or other DMARDs.
- Ulcerative Colitis (UC):
Used to treat adults with moderate to severe active ulcerative colitis (UC) who have not responded adequately to or cannot tolerate TNF blockers.
- Ankylosing Spondylitis (AS):
Recommended for adults with active ankylosing spondylitis (AS) who haven’t had good results from standard treatments.
- Polyarticular Course Juvenile Idiopathic Arthritis (pcJIA):
Approved for children 2 years and older with active polyarticular juvenile idiopathic arthritis (pcJIA).
Administration and Dosage
Xeljanz is available in two formulations:
- Immediate-release tablets: Typically taken twice daily.
- Extended-release tablets: Taken once daily.
Doctors determine the specific dosage and regimen based on the condition being treated. They also take into account how severe the disease is, as well as the patient’s overall health and how they respond to the treatment.
Xeljanz Price
Xeljanz cost per month starts from $30 to $4500.
Side Effects
Common side effects of Xeljanz include:
- Upper respiratory tract infections
- Headache
- Diarrhea
- Nasopharyngitis
- Increased cholesterol levels
Contraindications and Precautions
Patients who are allergic to Xeljanz should not take it. Doctors should be careful with patients who have a history of long-lasting or repeated infections, serious liver issues, or blood clots. They also recommend checking blood counts, liver enzymes, and cholesterol levels regularly during treatment.
Conclusion
Xeljanz is a big improvement in treating different autoimmune diseases, providing a pill option instead of injectable biologics. It effectively helps reduce inflammation and improves the quality of life for patients with long-term inflammatory conditions, making it a valuable treatment choice. However, because it can cause serious side effects, healthcare professionals need to carefully choose the right patients and keep a close eye on them during treatment.
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