Xeljanz 5 MG – 60 Tablets

Description

Xeljanz 5 mg: The Complete Medicine Guide to Uses, Safety, and Cost

Summary: Xeljanz 5 mg is an immediate-release tablet containing tofacitinib, a Janus Kinase (JAK) inhibitor used to treat immune-driven inflammatory diseases. It helps reduce pain, swelling, inflammation, and long-term joint or tissue damage.

Introduction

Living with an autoimmune disease is tough. The stiffness in the morning. The joint pain that won’t quit. The flare-ups that disrupt your week. You want relief. You want to get back to normal life.

For many, Xeljanz 5 mg is the answer.

Unlike many other treatments for rheumatoid arthritis or ulcerative colitis, Xeljanz isn’t a shot. It isn’t an IV drip. It is a simple pill.

Check Availability & Order Now

What is Xeljanz 5 mg?

Xeljanz 5 mg (generic name: tofacitinib) is an oral medication. It belongs to a class of drugs called Janus kinase (JAK) inhibitors. It is a small, film-coated tablet. You take it by mouth. It treats moderate to severe inflammatory conditions. Doctors prescribe it when other medicines, like methotrexate, fail to work. It was the first JAK inhibitor approved by the FDA. It changed the game. Before this, most advanced treatments were injectables. Now, patients have a powerful oral option.

At A Glance of Xeljanz Medicine:

Check Availability & Order Now

Conditions Xeljanz 5 mg Used For:

• Rheumatoid Arthritis (RA)
• Psoriatic Arthritis (PsA)
• Ulcerative Colitis (UC)
• Ankylosing Spondylitis (AS)
• Polyarticular-course Juvenile Idiopathic Arthritis (pcJIA)

It is often prescribed when TNF inhibitors fail or cause side effects.

Mechanism of Action: How Xeljanz 5 mg Works?

Xeljanz acts inside immune cells by blocking Janus kinase enzymes. These enzymes drive inflammation signals.

Step-by-Step Pathway (JAK–STAT)

1. Cytokines bind to receptors on immune cells.
2. This activates JAK enzymes (JAK1, JAK2, JAK3, TYK2).
3. JAKs activate STAT proteins.
4. STAT enters the cell nucleus and triggers inflammation genes.

Xeljanz interrupts this chain, reducing cytokine activity.

What This Means for Patients

• Less inflammation
• Less joint damage
• Fewer flare-ups
• Better mobility
• Long-term relief

Unlike biologics, Xeljanz works orally and starts acting quickly (2–6 weeks for RA, 8–14 weeks for UC).

Approved Uses for Xeljanz 5 mg

Xeljanz 5 mg uses cover a wide range of autoimmune disorders. It is FDA-approved for adults who have not responded well to TNF blockers.

1. Rheumatoid Arthritis (RA)

This is the most common use. It treats moderate to severe RA. It helps patients who didn’t get relief from methotrexate. It reduces joint tenderness. It prevents further bone damage.

2. Psoriatic Arthritis (PsA)

This condition affects skin and joints. Xeljanz helps control active PsA. It is often combined with non-biologic DMARDs. It helps improve physical function.

3. Ulcerative Colitis (UC)

UC causes inflammation in the colon. Xeljanz is used for moderate to severe cases. It helps induce remission. It also helps heal the lining of the gut.

4. Ankylosing Spondylitis (AS)

AS affects the spine. It causes fusion of the vertebrae. Xeljanz reduces pain and stiffness in the back. It improves mobility for AS patients.

5. Polyarticular-course Juvenile Idiopathic Arthritis (pcJIA)

This is for children aged 2 and older. It treats active pcJIA. It helps kids move better and feel less pain.

Note: Xeljanz 5 mg is an immediate-release tablet. There is also an extended-release version called Xeljanz XR (11 mg).

Therapeutic Indications for using Xeljanz 5 mg

Xeljanz 5 mg Uses for Rheumatoid Arthritis

Helps:

• Reduce joint pain
• Control swelling
• Improve morning stiffness
• Protect joints from damage

Best for: Patients who failed methotrexate or TNF inhibitors.Patients who failed methotrexate or TNF inhibitors.

Xeljanz 5 mg for Psoriatic Arthritis

Improves:

• Joint pain
• Dactylitis
• Enthesitis
• Skin symptoms
• Nail psoriasis

Often used with non-biologic DMARDs.

Xeljanz 5 mg for Ulcerative Colitis

Induction:

• 10 mg twice daily for 8 weeks

Maintenance:

• 5 mg twice daily

Helps:

• Achieve remission
• Reduce bleeding
• Improve stool frequency
• Heal mucosa

Xeljanz 5 mg for Ankylosing Spondylitis

Reduces:

• Back inflammation
• Morning stiffness
• Fatigue

Xeljanz 5 mg for pcJIA

For children ≥2 years, ≥40 kg

Dose:

• 5 mg twice daily (tablet or oral solution)

Dosage and Administration

Taking your medication correctly is vital. Always follow your doctor’s orders. Do not crush, split, or chew the tablet. Swallow it whole.

Typical Dosing Schedule

Special Dosing Considerations

• Renal Impairment: If you have kidney issues, your doctor may lower your dose to xeljanz 5 mg once daily.
• Liver Impairment: Moderate liver issues also require a dosage reduction.
• With Food: You can take xeljanz 5 mg with or without food.

Check Availability & Order Now

Regulatory Approvals & Clinical Trials for Xeljanz 5 mg

Xeljanz has one of the most extensive clinical trial programs among JAK inhibitors.

Approval Timeline

Key Clinical Trials

1. ORAL Solo

• RA patients who failed methotrexate
• Xeljanz produced higher ACR20/50 responses than placebo

2. ORAL Sync

• Added to methotrexate
• Marked improvement in joint tenderness and function

3. ORAL Surveillance (most important)

• Compared Xeljanz vs TNF inhibitors.

Findings:

• Higher rate of heart events
• Higher cancer signal
• Higher blood clot events

This triggered the FDA boxed warning, now essential for prescribing decisions.

Xeljanz 5 mg Safety Profile & Boxed Warnings

Xeljanz carries several FDA boxed warnings:

1. Serious infections

Raised risk for:

• TB
• Shingles
• Fungal infections
• Pneumonia

2. Heart-related problems

• Heart attack
• Stroke

Higher in patients with:

• Smoking history
• High cholesterol
• Over 50 years old

3. Blood clots (DVT/PE)

Risk increases with:

• Higher doses
• History of clots

4. Cancer risk

• Lymphoma
• Lung cancer
• Skin cancer

5. Death Risk

• Seen in high-risk RA patients on long-term therapy.

Common & Serious Side Effects of Xeljanz 5 mg

Common

• Fever
• Headache
• Diarrhea
• Upper respiratory infections
• High blood pressure
• Acne
• Shingles
• Increased cholesterol
• Nausea

Serious

• TB
• Severe infections
• Blood clots
• Heart attack
• Stroke
• GI perforation
• Liver injury
• Low blood cell count

Drug Interactions (CYP3A4 & CYP2C19)

Avoid combination with:

• Biologics (adalimumab, etanercept, infliximab)
• Strong immunosuppressants (azathioprine, cyclosporine)

CYP3A4 inhibitors increase Xeljanz levels

• Ketoconazole
• Clarithromycin

CYP3A4 inducers reduce effectiveness

• Rifampin
• Carbamazepine
• Phenytoin

Always update your doctor about all medicines – even herbal products.

Xeljanz 5 mg Price, Insurance & Patient Assistance

Average Monthly Price (USA):

• Xeljanz cost per month: $4,500 to $5,200  on an average (Brand)

At Emeregency Drug:

✔ Xeljanz 5 mg Price ≈ $4,500 USD

✔ Discounts may be available for bulk purchase (Contact our support via whatsapp / weChat)

✔ International shipping available

Ways to Reduce Cost:

• Insurance copay
• Pfizer Xeljanz Savings Program
• Patient Assistance Foundation
• Switch to Tofacent 5 mg / Tocit 5 mg / Tofaxen 5 mg / Tofacinix

Xeljanz 5 mg vs Alternatives / Cheaper Generics

Check Availability & Order Now

Real-World Evidence & Outcomes

Reported Benefits After 3 Months:

• Better pain control (RA/PsA)
• Reduced GI bleeding (UC)
• Improved mobility (AS)
• Fewer morning stiffness episodes

Long-Term Data:

• Stable remission possible
• Dose reduction possible after stabilization

Who Should Not Take Xeljanz 5 mg?

Avoid if you have:

• Active infection
• Untreated TB
• Severe liver disease
• History of blood clots
• Combination with biologics

Patient Tips for Safe Xeljanz Use

• Report fever, cough, or shingles immediately
• Avoid live vaccines
• Test for TB, Hepatitis B/C before starting
• Follow blood test schedule every 8–12 weeks
• Stay hydrated
• Maintain cholesterol check-ups
• Inform surgeon before any surgery

Conclusion

Xeljanz 5 mg is a powerful oral treatment for autoimmune diseases like RA, PsA, UC, AS, and pcJIA. It offers fast symptom relief, long-term disease control, and the convenience of an oral tablet.

However, it comes with important safety warnings that require monitoring, blood tests, and specialist supervision.

If you need:

• Authentic Xeljanz 5mg
• Affordable tofacitinib alternatives
• Global delivery
• Valid prescription required
• Customer support Available

👉 You can check availability and pricing at EmergencyDrug for the best verified options.

Check Availability & Order Now

FAQs

Q: Can I drink alcohol while taking Xeljanz? 

A: There is no direct interaction between Xeljanz and alcohol. However, Xeljanz is processed by the liver. Alcohol stresses the liver. Doctors usually recommend limiting intake.

Q: How fast does Xeljanz 5mg start working?

A: Most RA and PsA patients see improvement within 2–6 weeks, while UC patients may take 8–12 weeks to reach remission.

Q: Can I stop Xeljanz suddenly if I feel better?

A: No. Stopping suddenly can trigger flare-ups. Always taper under medical guidance.

Q: Can I cut the Xeljanz 5mg tablet in half? 

A: No. You should swallow the tablet whole. Do not crush, split, or chew it. This ensures the medicine releases correctly into your body.

Q: Is Xeljanz a steroid? 

A: No. It is not a steroid. It is a JAK inhibitor. It does not have the same long-term risks as corticosteroids (like prednisone), such as bone thinning or “moon face.”

Xeljanz 5 mg (Tofacitinib): Uses, Side Effects, Price & More

Get complete, updated information on Xeljanz 5 mg (Tofacitinib). Learn about uses for RA & UC, side effects, dosage, and the latest Xeljanz cost.

Product Brand: Xeljanz 5 MG

Product Currency: USD

Product Price: 4500

Product In-Stock: InStock

Editor's Rating:
5